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Music From Another Room is a romantic comedy that follows the exploits of Danny (Jude Law), a young man who grew up believing he was destined to marry the girl he helped deliver as a five year old boy when his neighbor went into emergency labor. Twenty-five years later, Danny returns to his hometown and finds the irresistible Anna Swann (Gretchen Mol) but she finds it easy to resist him since she is already engaged to dreamboat Eric (Jon Tenney, a very practical match.

In pursuit of Anna, Danny finds himself entangled with each of the eccentric Swanns including blind, sheltered Nina (Jennifer Tilly), cynical sister Karen (Martha Plimpton), big brother Bill (Jeremy Piven) and dramatic mother Grace (Brenda Blethyn) as he fights to prove that fate should never be messed with and passion should never be practical.